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Publications

Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12.

Altae-Tran H, Shmakov SA, Makarova KS, et al. Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12. Proceedings of the National Academy of Sciences of the United States of America. 2023;120(48):e2308224120. doi:10.1073/pnas.2308224120

Discovery of antibiotics that selectively kill metabolically dormant bacteria.

Zheng EJ, Valeri JA, Andrews IW, et al. Discovery of antibiotics that selectively kill metabolically dormant bacteria. Cell chemical biology. 2023. doi:10.1016/j.chembiol.2023.10.026

Spatial host-microbiome sequencing reveals niches in the mouse gut.

Lötstedt B, Stražar M, Xavier R, Regev A, Vickovic S. Spatial host-microbiome sequencing reveals niches in the mouse gut. Nature biotechnology. 2023. doi:10.1038/s41587-023-01988-1

Genetic retargeting of E3 ligases to enhance CAR T cell therapy.

Lane IC, Kembuan G, Carreiro J, et al. Genetic retargeting of E3 ligases to enhance CAR T cell therapy. Cell chemical biology. 2023. doi:10.1016/j.chembiol.2023.10.024

CHARR efficiently estimates contamination from DNA sequencing data.

Lu W, Gauthier LD, Poterba T, et al. CHARR efficiently estimates contamination from DNA sequencing data. American journal of human genetics. 2023;110(12):2068-2076. doi:10.1016/j.ajhg.2023.10.011

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.

LaFleur MW, Lemmen AM, Streeter ISL, et al. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system. Nature immunology. 2023. doi:10.1038/s41590-023-01689-6

Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries.

Nuttle X, Burt ND, Currall B, et al. Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries. Cell reports methods. 2023:100672. doi:10.1016/j.crmeth.2023.100672

Will variants of uncertain significance still exist in 2030?

Fowler DM, Rehm HL. Will variants of uncertain significance still exist in 2030? American journal of human genetics. 2023. doi:10.1016/j.ajhg.2023.11.005

Improving fine-mapping by modeling infinitesimal effects.

Cui R, Elzur RA, Kanai M, et al. Improving fine-mapping by modeling infinitesimal effects. Nature genetics. 2023. doi:10.1038/s41588-023-01597-3

A genetic history of the Balkans from Roman frontier to Slavic migrations.

Olalde I, Carrión P, Mikić I, et al. A genetic history of the Balkans from Roman frontier to Slavic migrations. Cell. 2023;186(25):5472-5485.e9. doi:10.1016/j.cell.2023.10.018