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Publications

Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma.

Li K, Tolman N, Segrè A V, et al. Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.18.633745

Histotechnology at the crossroad of spatial biology: bridging legacy and innovation.

Wang S, Wang Y, Krull D. Histotechnology at the crossroad of spatial biology: bridging legacy and innovation. Journal of histotechnology. 2025:1-6. doi:10.1080/01478885.2025.2456415

Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance.

Phan T, Ribeiro RM, Edelstein GE, et al. Modeling suggests SARS-CoV-2 rebound after nirmatrelvir-ritonavir treatment is driven by target cell preservation coupled with incomplete viral clearance. Journal of virology. 2025:e0162324. doi:10.1128/jvi.01623-24

Multi-locus CRISPRi targeting with a single truncated guide RNA.

Moore MM, Wekhande S, Issner R, et al. Multi-locus CRISPRi targeting with a single truncated guide RNA. Nature communications. 2025;16(1):1357. doi:10.1038/s41467-025-56144-x

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease.

Schunkert H, Di Angelantonio E, Inouye M, et al. Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease. European heart journal. 2025. doi:10.1093/eurheartj/ehae649

zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters.

Salamzade R, Tran PQ, Martin C, et al. zol and fai: large-scale targeted detection and evolutionary investigation of gene clusters. Nucleic acids research. 2025;53(3). doi:10.1093/nar/gkaf045

Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study.

Brennan SO, Kelly PJ, Gorey S, et al. Genetically Predicted IL-18 Inhibition and Risk of Cardiovascular Events: A Mendelian Randomization Study. Circulation. 2025;151(5):334-336. doi:10.1161/CIRCULATIONAHA.124.072238

Introducing the Global Alliance for Spatial Technologies (GESTALT).

Plummer JT, Vlachos IS, Martelotto LG. Introducing the Global Alliance for Spatial Technologies (GESTALT). Nature genetics. 2025. doi:10.1038/s41588-024-02066-1

Clonal Hematopoiesis Associates with Prevalent and Incident Cardiometabolic Disease in High-Risk Individuals.

Regan JA, Kwee LC, Nafissi NA, et al. Clonal Hematopoiesis Associates with Prevalent and Incident Cardiometabolic Disease in High-Risk Individuals. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.01.14.25320566

Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity.

Danzi MC, Xu IRL, Fazal S, et al. Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.06.631535