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Publications

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood.

Gupta R, Durham TJ, Chau G, et al. Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.25.655566

Human genetic variation shapes the response of neurons to interferons.

Andzelm MM, Bolshakova S, Pettinari N, et al. Human genetic variation shapes the response of neurons to interferons. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.28.653507

SCOT+: A Comprehensive Software Suite for Single-Cell alignment Using Optimal Transport.

Baker C, Pham T, Demetci P, et al. SCOT+: A Comprehensive Software Suite for Single-Cell alignment Using Optimal Transport. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.21.655322

Brieflow: An Integrated Computational Pipeline for High-Throughput Analysis of Optical Pooled Screening Data.

Di Bernardo M, Kern RS, Mallar A, Nutter-Upham A, Blainey PC, Cheeseman I. Brieflow: An Integrated Computational Pipeline for High-Throughput Analysis of Optical Pooled Screening Data. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.26.656231

Cell-type-specific patterns and consequences of somatic mutation in development and aging brain.

Kriz AJ, Mao S, Shao DD, et al. Cell-type-specific patterns and consequences of somatic mutation in development and aging brain. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.30.656844

Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex.

Bolshakova S, Sifuentes SEC, Phadke RA, et al. Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.29.656749

Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts.

Konigsberg IR, Vargas LB, Pratte KA, et al. Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.06.01.25328699

A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study.

Atabaki NN, Coral DE, Pomares-Millan H, et al. A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.06.02.25328773

Putting Polygenic Scores in Context: How Intersectional Factors Affect Relative and Absolute Genetic Risk.

Cudic M, Tubbs JD, Ge T, Smoller JW. Putting Polygenic Scores in Context: How Intersectional Factors Affect Relative and Absolute Genetic Risk. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.06.04.25328987

Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavior.

Gunter-Rahman F, Mallett S, White F, et al. Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavior. iScience. 2025;28(6):112636. doi:10.1016/j.isci.2025.112636