Publications

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation.

Kaas M, Chofflet N, Bicer D, et al. Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation. Research square. 2025. doi:10.21203/rs.3.rs-5928514/v1

Rapid emergence of resistance to broad-spectrum direct antimicrobial activity of avibactam.

Nägeli M, Rodriguez S, Iradukunda A, Manson AL, Earl AM, Brennan-Krohn T. Rapid emergence of resistance to broad-spectrum direct antimicrobial activity of avibactam. Microbiology spectrum. 2025;13(8):e0324124. doi:10.1128/spectrum.03241-24

Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape.

Muir DF, Asper GPR, Notin P, et al. Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape. Science (New York, N.Y.). 2025;388(6752):eadu1058. doi:10.1126/science.adu1058

Pan-viral ORFs discovery using massively parallel ribosome profiling.

Weingarten-Gabbay S, Bauer MR, Stanton AC, et al. Pan-viral ORFs discovery using massively parallel ribosome profiling. Science (New York, N.Y.). 2025;388(6752):1218-1224. doi:10.1126/science.ado6670

A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD.

Gerdemann U, Kimler K, Warren MR, et al. A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD. Blood. 2025;146(9):1127-1141. doi:10.1182/blood.2024027239

Long-acting oral weekly risperidone (LYN-005) for schizophrenia in the USA (STARLYNG-1): a multicentre, open-label, non-randomised phase 3 trial.

Citrome L, Nagaraj N, Traverso G, Dumas T, Scranton R. Long-acting oral weekly risperidone (LYN-005) for schizophrenia in the USA (STARLYNG-1): a multicentre, open-label, non-randomised phase 3 trial. The lancet. Psychiatry. 2025;12(7):504-512. doi:10.1016/S2215-0366(25)00135-X

Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance.

Dorans E, Jagadeesh K, Dey K, Price AL. Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance. Nature genetics. 2025;57(7):1649-1658. doi:10.1038/s41588-025-02220-3

Protective exercise responses in the dentate gyrus of Alzheimer's disease mouse model revealed with single-nucleus RNA-sequencing.

da Rocha JF, Lance ML, Luo R, et al. Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. Nature neuroscience. 2025;28(7):1546-1561. doi:10.1038/s41593-025-01971-w

Development of a Novel Biomarker Platform for Profiling Key Protein-Protein Interactions to Predict the Efficacy of BH3-Mimetic Drugs.

Kinloch AJ, Rahman F, Karakas B, et al. Development of a Novel Biomarker Platform for Profiling Key Protein-Protein Interactions to Predict the Efficacy of BH3-Mimetic Drugs. Cancers. 2025;17(11). doi:10.3390/cancers17111852

Patient-derived organotypic tumor spheroids, tumoroids, and organoids: advancing immunotherapy using state-of-the-art 3D tumor model systems.

Bozym DJ, Zheng DX, Revach OY, Aref A, Jenkins RW. Patient-derived organotypic tumor spheroids, tumoroids, and organoids: advancing immunotherapy using state-of-the-art 3D tumor model systems. Lab on a chip. 2025;25(13):3038-3059. doi:10.1039/d5lc00062a

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Publications

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