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Publications

Cohort design and natural language processing to reduce bias in electronic health records research.

Khurshid S, Reeder C, Harrington LX, et al. Cohort design and natural language processing to reduce bias in electronic health records research. NPJ Digit Med. 2022;5(1):47. doi:10.1038/s41746-022-00590-0

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

Trubetskoy V, Pardiñas AF, Qi T, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022. doi:10.1038/s41586-022-04434-5

Rational Design of Silicon-Based Zinc Ionophores.

Yamada K, Deb A, Shoba VM, et al. Rational Design of Silicon-Based Zinc Ionophores. Angew Chem Int Ed Engl. 2022:e202201698. doi:10.1002/anie.202201698

Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.

Salamzade R, Manson AL, Walker BJ, et al. Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance. Genome Med. 2022;14(1):37. doi:10.1186/s13073-022-01040-y

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.

Mok BY, Kotrys AV, Raguram A, Huang TP, Mootha VK, Liu DR. CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01256-8

TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.

MacDonald BT, Keshishian H, Mundorff CC, et al. TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease. Mol Cell Proteomics. 2022;21(4):100223. doi:10.1016/j.mcpro.2022.100223

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.

Larson RC, Kann MC, Bailey SR, et al. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature. 2022;604(7906):563-570. doi:10.1038/s41586-022-04585-5

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Singh T, Poterba T, Curtis D, et al. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022;604(7906):509-516. doi:10.1038/s41586-022-04556-w

Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study.

El-Khoury H, Lee DJ, Alberge JB, et al. Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study. Lancet Haematol. 2022. doi:10.1016/S2352-3026(22)00069-2

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

Joung J, Kirchgatterer PC, Singh A, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13(1):1606. doi:10.1038/s41467-022-29205-8