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Publications

Systematic identification of biomarker-driven drug combinations to overcome resistance.

Rees MG, Brenan L, Carmo M do, et al. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nat Chem Biol. 2022. doi:10.1038/s41589-022-00996-7

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors.

Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, Raychaudhuri S. HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors. Nat Genet. 2022. doi:10.1038/s41588-022-01032-z

Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.

Patel SJ, Liu N, Piaker S, et al. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022;14(637):eabh3831. doi:10.1126/scitranslmed.abh3831

Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.

Bloem B, Huda R, Amemori KI, et al. Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task. Nat Commun. 2022;13(1):1541. doi:10.1038/s41467-022-28983-5

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

Sebastián C, Ferrer C, Serra M, et al. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022;13(1):1503. doi:10.1038/s41467-022-29085-y

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.

Mead BE, Hattori K, Levy L, et al. Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00863-9

Copper induces cell death by targeting lipoylated TCA cycle proteins.

Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375(6586):1254-1261. doi:10.1126/science.abf0529

Genetic modifiers of Huntington disease differentially influence motor and cognitive domains.

Lee JM, Huang Y, Orth M, et al. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. Am J Hum Genet. 2022. doi:10.1016/j.ajhg.2022.03.004

Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae.

Brennan-Krohn T, Grote A, Rodriguez S, Kirby JE, Earl AM. Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2022;66(3):e0196921. doi:10.1128/aac.01969-21

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.

Zhang YL, Moran SP, Allen A, et al. Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacol Transl Sci. 2022;5(3):156-168. doi:10.1021/acsptsci.1c00233