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Publications

Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy.

Miller PG, Sperling AS, Brea EJ, et al. Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy. Blood Adv. 2021;5(15):2982-2986. doi:10.1182/bloodadvances.2021004554

Deep learning to design nuclear-targeting abiotic miniproteins.

Schissel CK, Mohapatra S, Wolfe JM, et al. Deep learning to design nuclear-targeting abiotic miniproteins. Nat Chem. 2021. doi:10.1038/s41557-021-00766-3

Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.

Mizoguchi T, MacDonald BT, Bhandary B, et al. Coronary Disease Association With ADAMTS7 Is Due to Protease Activity. Circ Res. 2021;129(4):458-470. doi:10.1161/CIRCRESAHA.121.319163

SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations.

Margiotta E, Guerra CF. SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations. Comput Theor Chem. 2021:113392. doi:10.1016/j.comptc.2021.113392

A proteogenomic portrait of lung squamous cell carcinoma.

Satpathy S, Krug K, Beltran PMJ, et al. A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021;184(16):4348-4371.e40. doi:10.1016/j.cell.2021.07.016

Augmenting and directing long-range CRISPR-mediated activation in human cells.

Tak E, Horng JE, Perry NT, et al. Augmenting and directing long-range CRISPR-mediated activation in human cells. Nat Methods. 2021. doi:10.1038/s41592-021-01224-1

De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.

Fukuda A, Hazelbaker DZ, Motosugi N, et al. De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells. Stem Cell Reports. 2021. doi:10.1016/j.stemcr.2021.07.015

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.

McKinney DC, McMillan BJ, Ranaghan MJ, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021. doi:10.1021/acs.jmedchem.1c00507

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

Pikman Y, Ocasio-Martinez N, Alexe G, et al. Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. Leukemia. 2021. doi:10.1038/s41375-021-01361-8

PRICKLE2 revisited-further evidence implicating PRICKLE2 in neurodevelopmental disorders.

Bayat A, Iqbal S, Borredy K, et al. PRICKLE2 revisited-further evidence implicating PRICKLE2 in neurodevelopmental disorders. Eur J Hum Genet. 2021;29(8):1235-1244. doi:10.1038/s41431-021-00912-y