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Publications

Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis.

Yammine KM, Abularach SM, Xiong M, et al. Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis. The Journal of biological chemistry. 2025;301(8):110436. doi:10.1016/j.jbc.2025.110436

Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs.

Wu H, Zhang J, Tan L, Xie XS. Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs. Nature genetics. 2025;57(7):1777-1786. doi:10.1038/s41588-025-02247-6

Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.

Edmonds KK, Wilkinson ME, Strebinger D, et al. Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons. Nature communications. 2025;16(1):6079. doi:10.1038/s41467-025-61321-z

Advances, challenges, and opportunities of human midbrain organoids for modelling of the dopaminergic system.

Fiorenzano A, Sozzi E, Kastli R, et al. Advances, challenges, and opportunities of human midbrain organoids for modelling of the dopaminergic system. The EMBO journal. 2025;44(15):4181-4195. doi:10.1038/s44318-025-00494-1

Malignant Transformation of Glioblastoma: One Step at a Time.

J Y Lee J, Suvà ML. Malignant Transformation of Glioblastoma: One Step at a Time. Cancer discovery. 2025;15(7):1312-1314. doi:10.1158/2159-8290.CD-25-0698

Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD.

Bhattacharya R, Marnell CS, Cho SMJ, et al. Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD. Circulation. Genomic and precision medicine. 2025;18(4):e004937. doi:10.1161/CIRCGEN.124.004937

Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms.

Li S, Stuhr NL, Ahsan F, et al. Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms. iScience. 2025;28(7):112827. doi:10.1016/j.isci.2025.112827

Association of Health-Related Social Needs With Adverse Pregnancy Outcomes Among Black and Latina Individuals.

Belak L, James K, Rana M, et al. Association of Health-Related Social Needs With Adverse Pregnancy Outcomes Among Black and Latina Individuals. Obstetrics and gynecology. 2025;146(4):541-543. doi:10.1097/AOG.0000000000005999

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.

Severson TM, Minnee E, Zhu Y, et al. Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer. Cell reports. Medicine. 2025;6(7):102215. doi:10.1016/j.xcrm.2025.102215

The role of untranslated region variants in Mendelian disease: a review.

Wieder N, D’Souza EN, Dawes R, Chan A, Martin-Geary A, Whiffin N. The role of untranslated region variants in Mendelian disease: a review. European journal of human genetics : EJHG. 2025;33(9):1096-1105. doi:10.1038/s41431-025-01905-x