Publications

An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans.

Safina KR, Kotliar DA, Curtis M, et al. An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.09.01.673389

Blended Length Genome Sequencing (blend-seq): Combining Short Reads with Low-Coverage Long Reads to Maximize Variant Discovery.

Magner R, Cunial F, Basu S, et al. Blended Length Genome Sequencing (blend-seq): Combining Short Reads with Low-Coverage Long Reads to Maximize Variant Discovery. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2024.11.01.621515

Structural basis for the function of long noncoding RNA in neural stem cells.

Saha P, Patel S, Tavares RC, et al. Structural basis for the function of long noncoding RNA in neural stem cells. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.09.01.671568

Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway.

Sun Y, Li S, Mitra B, Zhong L, Zhang A, Gewurz BE. Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.09.06.674652

Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes.

Zhou Y, Ahsan FM, Li S, Soukas AA. Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.09.01.673564

The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases.

Hagenbeek FA, Richmond A, Tamlander M, et al. The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.09.02.25334913

Systematic analysis of snRNA genes reveals frequent variants in dominant and recessive developmental and epileptic encephalopathies.

Leitão E, Santini A, Cogne B, et al. Systematic analysis of snRNA genes reveals frequent variants in dominant and recessive developmental and epileptic encephalopathies. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.09.02.25334923

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk.

Ramste M, Weldy C, Kundu S, et al. Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.08.28.25334684

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores.

Jiang X, Price AL, Danesh J, et al. Exposure accumulation drives age-dependent disease architectures and polygenic risk scores. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.08.29.25334745

Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia.

Koedijk JB, Barneh F, Meesters-Ensing JE, et al. Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia. HemaSphere. 2025;9(9):e70212. doi:10.1002/hem3.70212