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Chemical Biology and Therapeutics Science Program
Chen J, Armstrong AH, Koehler AN, Hecht MH. Small molecule microarrays enable the discovery of compounds that bind the Alzheimer’s Aβ peptide and reduce its cytotoxicity. J Am Chem Soc. 2010;132(47):17015-22. doi:10.1021/ja107552s
Dančík V, Seiler KP, Young DW, Schreiber SL, Clemons PA. Distinct biological network properties between the targets of natural products and disease genes. J Am Chem Soc. 2010;132(27):9259-61. doi:10.1021/ja102798t
Koehler AN. A complex task? Direct modulation of transcription factors with small molecules. Curr Opin Chem Biol. 2010;14(3):331-40. doi:10.1016/j.cbpa.2010.03.022
Vegas AJ, Koehler AN. Detecting protein-small molecule interactions using fluorous small-molecule microarrays. Methods Mol Biol. 2010;669:43-55. doi:10.1007/978-1-60761-845-4_4
Tassa C, Duffner JL, Lewis TA, et al. Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjug Chem. 2010;21(1):14-9. doi:10.1021/bc900438a
Stanton BZ, Peng LF, Maloof N, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009;5(3):154-6. doi:10.1038/nchembio.142
Vegas AJ, Fuller JH, Koehler AN. Small-molecule microarrays as tools in ligand discovery. Chem Soc Rev. 2008;37(7):1385-94. doi:10.1039/b703568n
Nieland TJF, Shaw JT, Jaipuri FA, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008;47(1):460-72. doi:10.1021/bi701277x
Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN. Detecting binding interactions using microarrays of natural product extracts. J Am Chem Soc. 2007;129(37):11346-7. doi:10.1021/ja073965s