Freedy A, Liau B. Discovering new biology with drug-resistance alleles. Nature chemical biology. 2021;17(12):1219-1229. doi:10.1038/s41589-021-00865-9
Chemical Biology and Therapeutics Science Program
Koga Y, Hoang E, Park Y, et al. Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Journal of the American Chemical Society. 2021;143(34):13473-13477. doi:10.1021/jacs.1c05146
Yang K, Lee M, Jones PA, et al. A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Sci Adv. 2020;6(47). doi:10.1126/sciadv.abc3207
Del Amo VL, Leger BS, Cox KJ, et al. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Rep. 2020;31(13):107841. doi:10.1016/j.celrep.2020.107841
Modell AE, Siriwardena SU, Choudhary A. A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems. Biochemistry. 2020;59(20):1869-1870. doi:10.1021/acs.biochem.0c00273
Long K, Alphey L, Annas G, et al. Core commitments for field trials of gene drive organisms. Science (New York, N.Y.). 2020;370(6523):1417-1419. doi:10.1126/science.abd1908
Sreekanth V, Zhou Q, Kokkonda P, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS central science. 2020;6(12):2228-2237. doi:10.1021/acscentsci.0c00129
Lim D, Sreekanth V, Cox KJ, et al. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Nature communications. 2020;11(1):4043. doi:10.1038/s41467-020-17725-0
Siriwardena SU, Godage DNPM, Shoba VM, et al. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. 2020;142(33):14052-14057. doi:10.1021/jacs.0c05537
Lee M, Maji B, Manna D, et al. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Journal of the American Chemical Society. 2020;142(14):6477-6482. doi:10.1021/jacs.0c00099