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Chemical Biology and Therapeutics Science Program

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders.

Gosavi P, Ngan K, Yeo M, et al. Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders. ACS central science. 2022;8(4):417-429. doi:10.1021/acscentsci.1c01603

CRISPR-based therapeutics: current challenges and future applications.

Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: current challenges and future applications. Trends in pharmacological sciences. 2022;43(2):151-161. doi:10.1016/j.tips.2021.10.012

Discovering new biology with drug-resistance alleles.

Freedy A, Liau B. Discovering new biology with drug-resistance alleles. Nature chemical biology. 2021;17(12):1219-1229. doi:10.1038/s41589-021-00865-9

Reconstruction of evolving gene variants and fitness from short sequencing reads.

Shen MW, Zhao KT, Liu DR. Reconstruction of evolving gene variants and fitness from short sequencing reads. Nature chemical biology. 2021;17(11):1188-1198. doi:10.1038/s41589-021-00876-6

In vivo somatic cell base editing and prime editing.

Newby GA, Liu DR. In vivo somatic cell base editing and prime editing. Molecular therapy : the journal of the American Society of Gene Therapy. 2021;29(11):3107-3124. doi:10.1016/j.ymthe.2021.09.002

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.

Koblan LW, Arbab M, Shen MW, et al. Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nature biotechnology. 2021;39(11):1414-1425. doi:10.1038/s41587-021-00938-z

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29. doi:10.1016/j.cell.2021.09.018

Disulfide-compatible phage-assisted continuous evolution in the periplasmic space.

Morrison MS, Wang T, Raguram A, Hemez C, Liu DR. Disulfide-compatible phage-assisted continuous evolution in the periplasmic space. Nature communications. 2021;12(1):5959. doi:10.1038/s41467-021-26279-8

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors.

Krishnamurthy S, Traore S, Cooney AL, et al. Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors. Nucleic acids research. 2021;49(18):10558-10572. doi:10.1093/nar/gkab788

Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.

Koga Y, Hoang E, Park Y, et al. Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Journal of the American Chemical Society. 2021;143(34):13473-13477. doi:10.1021/jacs.1c05146