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Chemical Biology and Therapeutics Science Program
Koga Y, Hoang E, Park Y, et al. Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Journal of the American Chemical Society. 2021;143(34):13473-13477. doi:10.1021/jacs.1c05146
Krishnamurthy S, Traore S, Cooney AL, et al. Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors. Nucleic acids research. 2021;49(18):10558-10572. doi:10.1093/nar/gkab788
Modell AE, Lai S, Nguyen TM, Choudhary A. Bifunctional modalities for repurposing protein function. Cell chemical biology. 2021;28(7):1081-1089. doi:10.1016/j.chembiol.2021.06.005
Blum T, Liu H, Packer MS, et al. Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science (New York, N.Y.). 2021;371(6531):803-810. doi:10.1126/science.abf5972
Huang TP, Newby GA, Liu DR. Precision genome editing using cytosine and adenine base editors in mammalian cells. Nature protocols. 2021;16(2):1089-1128. doi:10.1038/s41596-020-00450-9
Freedy A, Liau B. Discovering new biology with drug-resistance alleles. Nature chemical biology. 2021;17(12):1219-1229. doi:10.1038/s41589-021-00865-9
Newby GA, Liu DR. In vivo somatic cell base editing and prime editing. Molecular therapy : the journal of the American Society of Gene Therapy. 2021;29(11):3107-3124. doi:10.1016/j.ymthe.2021.09.002
Gao P, Lyu Q, Ghanam A, et al. Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression. Genome biology. 2021;22(1):83. doi:10.1186/s13059-021-02304-3
Podracky CJ, An C, DeSousa A, Dorr BM, Walsh D, Liu DR. Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nature chemical biology. 2021;17(3):317-325. doi:10.1038/s41589-020-00706-1