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Publications

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

Wagner FF, Weïwer M, Steinbacher S, et al. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016;24(18):4008-4015. doi:10.1016/j.bmc.2016.06.040

Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.

Buvall L, Wallentin H, Sieber J, et al. Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes. J Am Soc Nephrol. 2016. doi:10.1681/ASN.2016040414

A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution.

Zhou X, Blocker AW, Airoldi EM, O’Shea EK. A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution. Elife. 2016;5. doi:10.7554/eLife.16970

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Obeng EA, Chappell RJ, Seiler M, et al. Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. Cancer Cell. 2016;30(3):404-17. doi:10.1016/j.ccell.2016.08.006

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.

Haftchenary S, Nelson SD, Furst L, et al. Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments. ACS Comb Sci. 2016;18(9):569-74. doi:10.1021/acscombsci.6b00050

Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

Hsu YH, Li G, Liu CT, et al. Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variants: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study. Hum Mol Genet. 2016. doi:10.1093/hmg/ddw289

CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development.

Ray MK, Wiskow O, King MJ, et al. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016;291(37):19558-72. doi:10.1074/jbc.M116.730853

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science. 2016;353(6304):1161-5. doi:10.1126/science.aaf5171

MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle.

Del Rosario RCH, Damasco JRC, Aguda BD. MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle. Sci Rep. 2016;6:32823. doi:10.1038/srep32823

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

Wang Y, Wach JY, Sheehan P, et al. Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β. ACS Med Chem Lett. 2016;7(9):852-6. doi:10.1021/acsmedchemlett.6b00230