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Publications

A prime editor mouse to model a broad spectrum of somatic mutations in vivo.

Ely ZA, Mathey-Andrews N, Naranjo S, et al. A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Nature biotechnology. 2023. doi:10.1038/s41587-023-01783-y

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover.

Huang M, Claussnitzer M, Saadat A, Coral DE, Kalamajski S, Franks PW. Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover. Diabetologia. 2023. doi:10.1007/s00125-023-05915-6

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Aryal S, Bonanno K, Song B, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell reports. 2023;42(5):112497. doi:10.1016/j.celrep.2023.112497

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.

Prentice KJ, Lee A, Cedillo P, et al. Sympathetic tone dictates the impact of lipolysis on FABP4 secretion. Journal of lipid research. 2023:100386. doi:10.1016/j.jlr.2023.100386

Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis.

von Glehn F, Pochet N, Thapa B, et al. Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis. International journal of molecular sciences. 2023;24(9). doi:10.3390/ijms24098000

Novel patients with NHLRC2 variants expand the phenotypic spectrum of FINCA disease.

Tallgren A, Kager L, O’Grady G, et al. Novel patients with NHLRC2 variants expand the phenotypic spectrum of FINCA disease. Frontiers in neuroscience. 2023;17:1123327. doi:10.3389/fnins.2023.1123327

Chronotype Polygenic Score and the Timing and Quality of Workplace Cafeteria Purchases: Secondary Analysis of the ChooseWell 365 Randomized Controlled Trial.

Dashti HS, Alimenti K, Levy DE, et al. Chronotype Polygenic Score and the Timing and Quality of Workplace Cafeteria Purchases: Secondary Analysis of the ChooseWell 365 Randomized Controlled Trial. Current developments in nutrition. 2023;7(3):100048. doi:10.1016/j.cdnut.2023.100048

Editorial: The advances in proteomics and targeted therapy of malignant brain tumours.

Chen A, An Z. Editorial: The advances in proteomics and targeted therapy of malignant brain tumours. Frontiers in oncology. 2023;13:1195847. doi:10.3389/fonc.2023.1195847

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients.

Malhotra S, Midaglia L, Chuquisana O, et al. The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients. European journal of neurology. 2023. doi:10.1111/ene.15866

Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death.

Byrne AB, Arts P, Ha TT, et al. Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death. Nature medicine. 2023;29(1):180-189. doi:10.1038/s41591-022-02142-1