Publications

The female protective effect against autism spectrum disorder.

Wigdor EM, Weiner DJ, Grove J, et al. The female protective effect against autism spectrum disorder. Cell genomics. 2022;2(6):100134. doi:10.1016/j.xgen.2022.100134

Global priorities for large-scale biomarker-based prospective cohorts.

Collins R, Balaconis MK, Brunak S, et al. Global priorities for large-scale biomarker-based prospective cohorts. Cell genomics. 2022;2(6):100141. doi:10.1016/j.xgen.2022.100141

Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes.

Karczewski KJ, Solomonson M, Chao KR, et al. Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes. Cell genomics. 2022;2(9):100168. doi:10.1016/j.xgen.2022.100168

Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists and .

Orsi D, Pook E, Bräuer N, et al. Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists and . Journal of medicinal chemistry. 2022;65(21):14843-14863. doi:10.1021/acs.jmedchem.2c01379

Morphology and gene expression profiling provide complementary information for mapping cell state.

Way G, Natoli T, Adeboye A, et al. Morphology and gene expression profiling provide complementary information for mapping cell state. Cell systems. 2022;13(11):911-923.e9. doi:10.1016/j.cels.2022.10.001

An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with Efficacy against Drug-Resistant Gram-Negative Infections.

Parker E, Cain B, Hajian B, et al. An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with Efficacy against Drug-Resistant Gram-Negative Infections. ACS central science. 2022;8(8):1145-1158. doi:10.1021/acscentsci.2c00598

Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations.

Shekhar M, Gupta C, Suzuki K, Chan C, Murata T, Singharoy A. Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations. ACS central science. 2022;8(7):915-925. doi:10.1021/acscentsci.1c01599

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.

Miller P, Sathappa M, Moroco J, et al. Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature communications. 2022;13(1):3778. doi:10.1038/s41467-022-30463-9

Systematic profiling of conditional degron tag technologies for target validation studies.

Bondeson D, Mullin-Bernstein Z, Oliver S, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nature communications. 2022;13(1):5495. doi:10.1038/s41467-022-33246-4

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.

Kwon J, Hajian B, Bian Y, et al. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022;609(7926):408-415. doi:10.1038/s41586-022-04928-2

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Publications

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