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Publications

A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening.

Boivin B, Roet KCD, Huang X, et al. A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening. Mol Biol Cell. 2021:mbcE21100481. doi:10.1091/mbc.E21-10-0481

In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris.

Rybak JM, Barker KS, Muñoz JF, et al. In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris. Clin Microbiol Infect. 2021. doi:10.1016/j.cmi.2021.11.024

Identification of Inhibitors of Fungal Fatty Acid Biosynthesis.

DeJarnette C, Meyer CJ, Jenner AR, et al. Identification of Inhibitors of Fungal Fatty Acid Biosynthesis. ACS Infect Dis. 2021;7(12):3210-3223. doi:10.1021/acsinfecdis.1c00404

Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction.

Agrawal S, Klarqvist MDR, Emdin C, et al. Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction. Patterns (N Y). 2021;2(12):100364. doi:10.1016/j.patter.2021.100364

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.

Raghavan S, Winter PS, Navia AW, et al. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 2021;184(25):6119-6137.e26. doi:10.1016/j.cell.2021.11.017

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing.

Anzalone AV, Gao XD, Podracky CJ, et al. Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing. Nat Biotechnol. 2021. doi:10.1038/s41587-021-01133-w

Author Correction: Engineered pegRNAs improve prime editing efficiency.

Nelson JW, Randolph PB, Shen SP, et al. Author Correction: Engineered pegRNAs improve prime editing efficiency. Nat Biotechnol. 2021. doi:10.1038/s41587-021-01175-0

Age-related Diseases of Inflammation in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia.

Weeks LD, Marinac CR, Redd RA, et al. Age-related Diseases of Inflammation in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia. Blood. 2021. doi:10.1182/blood.2021014418

Mapping the human genetic architecture of COVID-19.

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021;600(7889):472-477. doi:10.1038/s41586-021-03767-x

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

Ito T, Young MJ, Li R, et al. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nat Genet. 2021;53(12):1664-1672. doi:10.1038/s41588-021-00967-z