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Publications

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.

Sato Y, Atarashi K, Plichta DR, et al. Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature. 2021;599(7885):458-464. doi:10.1038/s41586-021-03832-5

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29. doi:10.1016/j.cell.2021.09.018

Blastomycosis in Africa and the Middle East: A Comprehensive Review of Reported Cases and Reanalysis of Historical Isolates Based on Molecular Data.

Schwartz IS, Muñoz JF, Kenyon CR, et al. Blastomycosis in Africa and the Middle East: A Comprehensive Review of Reported Cases and Reanalysis of Historical Isolates Based on Molecular Data. Clin Infect Dis. 2021;73(7):e1560-e1569. doi:10.1093/cid/ciaa1100

Engineered pegRNAs improve prime editing efficiency.

Nelson JW, Randolph PB, Shen SP, et al. Engineered pegRNAs improve prime editing efficiency. Nat Biotechnol. 2021. doi:10.1038/s41587-021-01039-7

Joint single-cell measurements of nuclear proteins and RNA in vivo.

Chung H, Parkhurst CN, Magee EM, et al. Joint single-cell measurements of nuclear proteins and RNA in vivo. Nat Methods. 2021;18(10):1204-1212. doi:10.1038/s41592-021-01278-1

Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.

Wang M, Lee-Kim VS, Atri DS, et al. Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Circ Genom Precis Med. 2021;14(5):e003399. doi:10.1161/CIRCGEN.121.003399

A field guide to cultivating computational biology.

Way GP, Greene CS, Carninci P, et al. A field guide to cultivating computational biology. PLoS Biol. 2021;19(10):e3001419. doi:10.1371/journal.pbio.3001419

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer.

Coates JT, Sun S, Leshchiner I, et al. Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer. Cancer Discov. 2021;11(10):2436-2445. doi:10.1158/2159-8290.CD-21-0702

Biologically informed deep neural network for prostate cancer discovery.

Elmarakeby HA, Hwang J, Arafeh R, et al. Biologically informed deep neural network for prostate cancer discovery. Nature. 2021;598(7880):348-352. doi:10.1038/s41586-021-03922-4

Duplex-Repair enables highly accurate sequencing, despite DNA damage.

Xiong K, Shea D, Rhoades J, et al. Duplex-Repair enables highly accurate sequencing, despite DNA damage. Nucleic Acids Res. 2021. doi:10.1093/nar/gkab855