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Publications

Cellular and transcriptional diversity over the course of human lactation.

Nyquist SK, Gao P, Haining TKJ, et al. Cellular and transcriptional diversity over the course of human lactation. Proc Natl Acad Sci U S A. 2022;119(15):e2121720119. doi:10.1073/pnas.2121720119

Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia.

Palmer DS, Howrigan DP, Chapman SB, et al. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nat Genet. 2022. doi:10.1038/s41588-022-01034-x

An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis.

Cubillos-Ruiz A, Alcantar MA, Donghia NM, Cárdenas P, Avila-Pacheco J, Collins JJ. An engineered live biotherapeutic for the prevention of antibiotic-induced dysbiosis. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00871-9

Evaluating human genetic support for hypothesized metabolic disease genes.

Dornbos P, Singh P, Jang DK, et al. Evaluating human genetic support for hypothesized metabolic disease genes. Cell Metab. 2022. doi:10.1016/j.cmet.2022.03.011

Circuit topology predicts pathogenicity of missense mutations.

Woodard J, Iqbal S, Mashaghi A. Circuit topology predicts pathogenicity of missense mutations. Proteins. 2022. doi:10.1002/prot.26342

Cohort design and natural language processing to reduce bias in electronic health records research.

Khurshid S, Reeder C, Harrington LX, et al. Cohort design and natural language processing to reduce bias in electronic health records research. NPJ Digit Med. 2022;5(1):47. doi:10.1038/s41746-022-00590-0

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

Trubetskoy V, Pardiñas AF, Qi T, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022. doi:10.1038/s41586-022-04434-5

Rational Design of Silicon-Based Zinc Ionophores.

Yamada K, Deb A, Shoba VM, et al. Rational Design of Silicon-Based Zinc Ionophores. Angew Chem Int Ed Engl. 2022:e202201698. doi:10.1002/anie.202201698

Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance.

Salamzade R, Manson AL, Walker BJ, et al. Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance. Genome Med. 2022;14(1):37. doi:10.1186/s13073-022-01040-y

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.

Mok BY, Kotrys AV, Raguram A, Huang TP, Mootha VK, Liu DR. CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01256-8