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Publications

Intrapersonal Stability of Plasma Metabolomic Profiles over 10 Years among Women.

Zeleznik OA, Wittenbecher C, Deik A, et al. Intrapersonal Stability of Plasma Metabolomic Profiles over 10 Years among Women. Metabolites. 2022;12(5). doi:10.3390/metabo12050372

TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.

MacDonald BT, Keshishian H, Mundorff CC, et al. TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease. Mol Cell Proteomics. 2022;21(4):100223. doi:10.1016/j.mcpro.2022.100223

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.

Larson RC, Kann MC, Bailey SR, et al. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature. 2022;604(7906):563-570. doi:10.1038/s41586-022-04585-5

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Singh T, Poterba T, Curtis D, et al. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022;604(7906):509-516. doi:10.1038/s41586-022-04556-w

Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study.

El-Khoury H, Lee DJ, Alberge JB, et al. Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study. Lancet Haematol. 2022. doi:10.1016/S2352-3026(22)00069-2

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

Joung J, Kirchgatterer PC, Singh A, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13(1):1606. doi:10.1038/s41467-022-29205-8

Systematic identification of biomarker-driven drug combinations to overcome resistance.

Rees MG, Brenan L, Carmo M do, et al. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nat Chem Biol. 2022. doi:10.1038/s41589-022-00996-7

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors.

Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, Raychaudhuri S. HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors. Nat Genet. 2022. doi:10.1038/s41588-022-01032-z

Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.

Patel SJ, Liu N, Piaker S, et al. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022;14(637):eabh3831. doi:10.1126/scitranslmed.abh3831

Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.

Bloem B, Huda R, Amemori KI, et al. Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task. Nat Commun. 2022;13(1):1541. doi:10.1038/s41467-022-28983-5