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Imaging Platform

Genes in human obesity loci are causal obesity genes in C. elegans.

Ke W, Reed JN, Yang C, et al. Genes in human obesity loci are causal obesity genes in C. elegans. PLoS Genet. 2021;17(9):e1009736. doi:10.1371/journal.pgen.1009736

Deepometry, a framework for applying supervised and weakly supervised deep learning to imaging cytometry.

Doan M, Barnes C, McQuin C, et al. Deepometry, a framework for applying supervised and weakly supervised deep learning to imaging cytometry. Nat Protoc. 2021;16(7):3572-3595. doi:10.1038/s41596-021-00549-7

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging.

Tomov ML, O’Neil A, Abbasi HS, et al. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging. Commun Biol. 2021;4(1):786. doi:10.1038/s42003-021-02276-x

Which image-based phenotypes are most promising for using AI to understand cellular functions and why?

Lundberg E, Funke J, Uhlmann V, et al. Which image-based phenotypes are most promising for using AI to understand cellular functions and why? Cell Syst. 2021;12(5):384-387. doi:10.1016/j.cels.2021.04.012

ImageJ and CellProfiler: Complements in Open-Source Bioimage Analysis.

Dobson ETA, Cimini B, Klemm AH, Wählby C, Carpenter AE, Eliceiri KW. ImageJ and CellProfiler: Complements in Open-Source Bioimage Analysis. Curr Protoc. 2021;1(5):e89. doi:10.1002/cpz1.89

Developing open-source software for bioimage analysis: opportunities and challenges.

Levet F, Carpenter AE, Eliceiri KW, Kreshuk A, Bankhead P, Haase R. Developing open-source software for bioimage analysis: opportunities and challenges. F1000Res. 2021;10:302. doi:10.12688/f1000research.52531.1

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.

Carey KL, Paulus GLC, Wang L, et al. TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Rep. 2020;33(6):108371. doi:10.1016/j.celrep.2020.108371

CellProfiler 3.0: Next-generation image processing for biology.

McQuin C, Goodman A, Chernyshev V, et al. CellProfiler 3.0: Next-generation image processing for biology. PLoS Biol. 2018;16(7):e2005970. doi:10.1371/journal.pbio.2005970

Diagnostic Potential of Imaging Flow Cytometry.

Doan M, Vorobjev I, Rees P, et al. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018;36(7):649-652. doi:10.1016/j.tibtech.2017.12.008

Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.

Simm J, Klambauer G, Arany A, et al. Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery. Cell Chem Biol. 2018;25(5):611-618.e3. doi:10.1016/j.chembiol.2018.01.015