Evaluation of data discretization methods to derive platform independent isoform expression signatures for multi-class tumor subtyping. 1.Jung S, Bi Y, Davuluri RV. Evaluation of data discretization methods to derive platform independent isoform expression signatures for multi-class tumor subtyping. BMC Genomics. 2015;16 Suppl 11:S3. doi:10.1186/1471-2164-16-S11-S3. Read more
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. 1.Genovese G, Kähler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014;371(26):2477-87. doi:10.1056/NEJMoa1409405. Read more
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. 1.Perry JA, Kiezun A, Tonzi P, et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014;111(51):E5564-73. doi:10.1073/pnas.1419260111. Read more
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. 1.Rao SSP, Huntley MH, Durand NC, et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell. 2014;159(7):1665-80. doi:10.1016/j.cell.2014.11.021. Read more
Measuring missing heritability: inferring the contribution of common variants. 1.Golan D, Lander ES, Rosset S. Measuring missing heritability: inferring the contribution of common variants. Proc Natl Acad Sci U S A. 2014;111(49):E5272-81. doi:10.1073/pnas.1419064111. Read more
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. 1.Landau DA, Clement K, Ziller MJ, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell. 2014;26(6):813-25. doi:10.1016/j.ccell.2014.10.012. Read more
Escherichia coli O104:H4 Pathogenesis: an Enteroaggregative E. coli/Shiga Toxin-Producing E. coli Explosive Cocktail of High Virulence. 1.Navarro-Garcia F. Escherichia coli O104:H4 Pathogenesis: an Enteroaggregative E. coli/Shiga Toxin-Producing E. coli Explosive Cocktail of High Virulence. Microbiol Spectr. 2014;2(6). doi:10.1128/microbiolspec.EHEC-0008-2013. Read more
RNF43 is frequently mutated in colorectal and endometrial cancers. 1.Giannakis M, Hodis E, Mu XJ, et al. RNF43 is frequently mutated in colorectal and endometrial cancers. Nat Genet. 2014;46(12):1264-6. doi:10.1038/ng.3127. Read more
Comprehensive variation discovery in single human genomes. 1.Weisenfeld NI, Yin S, Sharpe T, et al. Comprehensive variation discovery in single human genomes. Nat Genet. 2014;46(12):1350-5. doi:10.1038/ng.3121. Read more
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites. 1.Engreitz JM, Sirokman K, McDonel P, et al. RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites. Cell. 2014;159(1):188-99. doi:10.1016/j.cell.2014.08.018. Read more