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Eric Lander

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.

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Andersen KG, Shapiro J, Matranga CB, et al. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 2015;162(4):738-50. doi:10.1016/j.cell.2015.07.020.

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.

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Cacchiarelli D, Trapnell C, Ziller MJ, et al. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 2015;162(2):412-24. doi:10.1016/j.cell.2015.06.016.

Brave New Genome.

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Lander ES. Brave New Genome. N Engl J Med. 2015;373(1):5-8. doi:10.1056/NEJMp1506446.

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.

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McHugh CA, Chen C-K, Chow A, et al. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. Nature. 2015;521(7551):232-6. doi:10.1038/nature14443.

Cutting the Gordian helix--regulating genomic testing in the era of precision medicine.

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Lander ES. Cutting the Gordian helix--regulating genomic testing in the era of precision medicine. N Engl J Med. 2015;372(13):1185-6. doi:10.1056/NEJMp1501964.

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.

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Kim H, Zheng S, Amini SS, et al. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 2015;25(3):316-27. doi:10.1101/gr.180612.114.

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

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Do R, Stitziel NO, Won H-H, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015;518(7537):102-6. doi:10.1038/nature13917.

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.

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Thormaehlen AS, Schuberth C, Won H-H, et al. Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction. PLoS Genet. 2015;11(2):e1004855. doi:10.1371/journal.pgen.1004855.

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

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Tonomura N, Elvers I, Thomas R, et al. Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers. PLoS Genet. 2015;11(2):e1004922. doi:10.1371/journal.pgen.1004922.

RNA antisense purification (RAP) for mapping RNA interactions with chromatin.

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Engreitz J, Lander ES, Guttman M. RNA antisense purification (RAP) for mapping RNA interactions with chromatin. Methods Mol Biol. 2015;1262:183-97. doi:10.1007/978-1-4939-2253-6_11.