Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. 1.Yassour M, Lim MY, Yun HS, et al. Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. Genome Med. 2016;8(1):17. doi:10.1186/s13073-016-0271-6. Read more
The Heroes of CRISPR. 1.Lander ES. The Heroes of CRISPR. Cell. 2016;164(1-2):18-28. doi:10.1016/j.cell.2015.12.041. Read more
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. 1.Kasar S, Kim J, Improgo R, et al. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun. 2015;6:8866. doi:10.1038/ncomms9866. Read more
Identification and characterization of essential genes in the human genome. 1.Wang T, Birsoy K, Hughes NW, et al. Identification and characterization of essential genes in the human genome. Science. 2015;350(6264):1096-101. doi:10.1126/science.aac7041. Read more
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. 1.Brastianos PK, Carter SL, Santagata S, et al. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015;5(11):1164-77. doi:10.1158/2159-8290.CD-15-0369. Read more
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. 1.Sanborn A, Rao S, Huang S, et al. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes. Proceedings of the National Academy of Sciences of the United States of America. 2015. doi:10.1073/pnas.1518552112. Read more
Mutations driving CLL and their evolution in progression and relapse. 1.Landau DA, Tausch E, Taylor-Weiner AN, et al. Mutations driving CLL and their evolution in progression and relapse. Nature. 2015;526(7574):525-30. doi:10.1038/nature15395. Read more
Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation. 1.Golan D, Rosset S, Lander ES. Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation. Proc Natl Acad Sci U S A. 2015;112(40):E5452-3. doi:10.1073/pnas.1511370112. Read more
Comprehensive assessment of cancer missense mutation clustering in protein structures. 1.Kamburov A, Lawrence MS, Polak P, et al. Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015;112(40):E5486-95. doi:10.1073/pnas.1516373112. Read more
Paired exome analysis of Barrett's esophagus and adenocarcinoma. 1.Stachler MD, Taylor-Weiner A, Peng S, et al. Paired exome analysis of Barrett’s esophagus and adenocarcinoma. Nat Genet. 2015;47(9):1047-55. doi:10.1038/ng.3343. Read more