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Publications

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

Sebastián C, Ferrer C, Serra M, et al. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022;13(1):1503. doi:10.1038/s41467-022-29085-y

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.

Mead BE, Hattori K, Levy L, et al. Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00863-9

Copper induces cell death by targeting lipoylated TCA cycle proteins.

Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375(6586):1254-1261. doi:10.1126/science.abf0529

Genetic modifiers of Huntington disease differentially influence motor and cognitive domains.

Lee JM, Huang Y, Orth M, et al. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. Am J Hum Genet. 2022. doi:10.1016/j.ajhg.2022.03.004

Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae.

Brennan-Krohn T, Grote A, Rodriguez S, Kirby JE, Earl AM. Transcriptomics Reveals How Minocycline-Colistin Synergy Overcomes Antibiotic Resistance in Multidrug-Resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2022;66(3):e0196921. doi:10.1128/aac.01969-21

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.

Zhang YL, Moran SP, Allen A, et al. Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacol Transl Sci. 2022;5(3):156-168. doi:10.1021/acsptsci.1c00233

Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments.

Yiu SPT, Guo R, Zerbe C, Weekes MP, Gewurz BE. Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments. Cell Rep. 2022;38(10):110411. doi:10.1016/j.celrep.2022.110411

StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities.

van Dijk LR, Walker BJ, Straub TJ, et al. StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities. Genome Biol. 2022;23(1):74. doi:10.1186/s13059-022-02630-0

Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis.

Chen R, Liu Y, Djekidel MN, et al. Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis. Sci Adv. 2022;8(9):eabm1077. doi:10.1126/sciadv.abm1077

Designing sensitive viral diagnostics with machine learning.

Metsky HC, Welch NL, Pillai PP, et al. Designing sensitive viral diagnostics with machine learning. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01213-5