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Publications

A unified model of human hemoglobin switching through single-cell genome editing.

Shen Y, Verboon JM, Zhang Y, et al. A unified model of human hemoglobin switching through single-cell genome editing. Nat Commun. 2021;12(1):4991. doi:10.1038/s41467-021-25298-9

Clonally expanded, GPR15-expressing pathogenic effector T2 cells are associated with eosinophilic esophagitis.

Morgan DM, Ruiter B, Smith NP, et al. Clonally expanded, GPR15-expressing pathogenic effector T2 cells are associated with eosinophilic esophagitis. Sci Immunol. 2021;6(62). doi:10.1126/sciimmunol.abi5586

Optimized liquid and gas phase fractionation increases HLA-peptidome coverage for primary cell and tissue samples.

Klaeger S, Apffel A, Clauser KR, et al. Optimized liquid and gas phase fractionation increases HLA-peptidome coverage for primary cell and tissue samples. Mol Cell Proteomics. 2021:100133. doi:10.1016/j.mcpro.2021.100133

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.

Lee JWJ, Plichta D, Hogstrom L, et al. Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease. Cell Host Microbe. 2021;29(8):1294-1304.e4. doi:10.1016/j.chom.2021.06.019

Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations.

Stražar M, Temba GS, Vlamakis H, et al. Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations. Nat Commun. 2021;12(1):4845. doi:10.1038/s41467-021-25213-2

Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy.

Miller PG, Sperling AS, Brea EJ, et al. Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy. Blood Adv. 2021;5(15):2982-2986. doi:10.1182/bloodadvances.2021004554

Deep learning to design nuclear-targeting abiotic miniproteins.

Schissel CK, Mohapatra S, Wolfe JM, et al. Deep learning to design nuclear-targeting abiotic miniproteins. Nat Chem. 2021. doi:10.1038/s41557-021-00766-3

Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.

Mizoguchi T, MacDonald BT, Bhandary B, et al. Coronary Disease Association With ADAMTS7 Is Due to Protease Activity. Circ Res. 2021;129(4):458-470. doi:10.1161/CIRCRESAHA.121.319163

SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations.

Margiotta E, Guerra CF. SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations. Comput Theor Chem. 2021:113392. doi:10.1016/j.comptc.2021.113392

A proteogenomic portrait of lung squamous cell carcinoma.

Satpathy S, Krug K, Beltran PMJ, et al. A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021;184(16):4348-4371.e40. doi:10.1016/j.cell.2021.07.016